Single Exposure of Bisphenol A (BPA) Affects Newborn Mouse Brain — Longterm Increases in Hyperactivity and Cognitive Effects
Viberg of the Eriksson lab in Sweden shows in a new paper in Toxicology (full text) that a single exposure to BPA on postnatal day 10 has dose-dependent effects. (Mice sexually mature around p45.)
The paper is still in press, so details are sparse, but authors saw changes in spontaneous behavior when exposed to a new environment, minor changes in cholenergic-system mediated behavior (responses to nicotine), but no changes in the spatial memory (Morris Water maze) or anxiety (elevated plus maze).
Here is a further article from science direct that includes quotes from the authors.
BPA was previously known to increase the risk of trisomies which cause disorders such as Down Syndrome–Full Text. It is extremely important to consider the risks since elevated levels are found in many environmental sources from receipts, plastic water bottles, canned foods, and even dentistry. BPA accumulates in the body over time, so it is important to be careful, especially if you are a woman planning on having children.
It is also important to note that hyperactivity in mice refers to increased activity and locomotion, which could result from many things and may have little or no relationship to the type of hyperactivity observed in children with ADHD.
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If you are interested in the effects of hormones on the brain, check out my post: MPA, the Hormone used in the Depo Provera birth control shot, causes memory problems in rats
Filed under: Behavior, Development, Mouse | Leave a Comment
Tags: BPA, Brain Development, Environmental Toxin, Mouse Behavior
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In Search of Memory -Eric Kandel
Kandel’s book is a nobel prize winner's memoir that spans from his Jewish childhood in Nazi-occupied Vienna to his work on sea slugs that uncovered synaptic plasticity, the molecular foundation of learning and memory. When I graduated college, every neuroscience major was given a copy of this book.
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